fluocinolone acetonide 21-acetate
fluocinolone acetonide 21-acetate
CAS: 356-12-7
Molecular Formula: C26H32F2O7
fluocinolone acetonide 21-acetate - Names and Identifiers
| Name | fluocinolone acetonide 21-acetate |
| Synonyms | Vanos Gelisyn Lidemol Cortalar Flucetonide Fluocinonide Fluocinonide(Vanos) Fluocinonide (100 mg) fluocinolone acetonide 21-acetate (6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione |
| CAS | 356-12-7 |
| EINECS | 206-597-6 |
| InChI | InChI=1/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 |
| InChIKey | WJOHZNCJWYWUJD-IUGZLZTKSA-N |
fluocinolone acetonide 21-acetate - Physico-chemical Properties
| Molecular Formula | C26H32F2O7 |
| Molar Mass | 494.52 |
| Density | 1.2001 (estimate) |
| Melting Point | 309 °C |
| Boling Point | 235°C (rough estimate) |
| Specific Rotation(α) | D +83° (chloroform) |
| Flash Point | 311.3°C |
| Water Solubility | 0.53mg/L(25 ºC) |
| Solubility | DMSO 99 mg/mL;Water <1 mg/mL;Ethanol <1 mg/mL. Soluble in acetone, slightly soluble in ethanol, insoluble in water |
| Vapor Presure | 1.97E-16mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | white to tan |
| pKa | 12.77±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.56 |
| MDL | MFCD00079302 |
| Physical and Chemical Properties | White or off-white crystalline powder. Melting point 308-311 °c. Soluble in acetone, slightly soluble in ethanol, insoluble in water, odorless, tasteless. |
fluocinolone acetonide 21-acetate - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R28 - Very Toxic if swallowed R63 - Possible risk of harm to the unborn child |
| Safety Description | S22 - Do not breathe dust. S25 - Avoid contact with eyes. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | TU3831000 |
| HS Code | 2937220000 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
fluocinolone acetonide 21-acetate - Reference Information
| Introduction | Fluocinolone acetate is also known as fluocinolone acetate, chemical name 6 α,9 α-difluoro-11β, 21-dihydroxy -16 α,17 α-[(1-Methylidene) Dioxy] Gesto-1, 4-Diethylene -3,20-Diketone -21-acetate, it is a powerful external anti-inflammatory glucocorticoid drug commonly used in clinic. It is widely used in the treatment of various diseases such as dermatitis, eczema, psoriasis, lupus erythematosus, lichen planus and osteoarthritis. |
| function and use | this product is a glucocorticoid containing fluorine. Local external application can contract dermal capillaries. Because it can inhibit DNA synthesis and affect cell metabolism, it can inhibit the proliferation or regeneration of epidermal cells. It can also inhibit the regeneration of fibroblasts and the formation of pigment cells in connective tissue. It can also stabilize the intracellular lysosomal membrane, prevent the intracellular lysosomal enzyme from releasing histamine and cause tissue damage, and is easily absorbed from the skin for external use. It has anti-inflammatory, antipruritic, anti-proliferative and immunosuppressive effects. after external use, it can be absorbed by complete skin, and the degree of absorption is affected by many factors, such as the matrix of the preparation, the pathological condition of the diseased skin, and whether the drug is sealed or not. After absorption, it binds to plasma proteins. It is mainly metabolized in the liver and excreted by the kidneys. for contact dermatitis, allergic dermatitis, seborrheic dermatitis, neurodermatitis, solar dermatitis, eczema, psoriasis, lichen planus and pruritus. |
| usage and dosage | topical application: apply this 0.025% ointment or cream evenly to the affected area, 2-3 times a day. The total amount in one week shall not exceed 12.5mg. The packet is only suitable for chronic hypertrophy or palmoplantar lesions. |
| adverse reactions | long-term or large-scale application, especially when closed therapy is adopted, systemic adverse reactions can be caused by absorption. clinical symptoms include Cushing's syndrome, hyperglycemia, diabetes, etc. Long-term or large-scale application can also cause skin atrophy, telangiectasia, acne-like dermatitis, perioral dermatitis, folliculitis, and can induce skin infections and aggravate infectious skin diseases. |
| precautions | 1. those who are allergic to this product and those who are allergic to tuberculosis, viral, fungal and bacterial skin are prohibited. Use with caution for pregnant and lactating women. Babies should also be used with caution. 2. Patients with skin diseases complicated with bacteria should be infected with antibacterial drugs. 3. It should not be used for large-area skin damage, nor can it be used for a long time or a large area to avoid absorption and poisoning. 4. Long-term application of multiple times a day can cause drug resistance, so do not apply too many times, and intermittent medication can be used. |
| use | for allergic dermatitis, eczema, etc. |
Last Update：2024-04-09 20:49:11
Supplier List
Spot supply
Product Name: Fluocinolone Acetonide Impurity 13 (Fluocinolone Acetonide EP Impurity M)(Fluocinonide) Visit Supplier Webpage Request for quotationCAS: 356-12-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: fluocinolone acetonide 21-acetate Request for quotationCAS: 356-12-7
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: fluocinolone acetonide 21-acetate Request for quotation
CAS: 356-12-7
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 356-12-7
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Multiple SpecificationsSpot supply
Product Name: Fluocinolone acetonide Visit Supplier Webpage Request for quotationCAS: 356-12-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Fluocinolone Acetonide Impurity 13 (Fluocinolone Acetonide EP Impurity M)(Fluocinonide) Visit Supplier Webpage Request for quotationCAS: 356-12-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: fluocinolone acetonide 21-acetate Request for quotationCAS: 356-12-7
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: fluocinolone acetonide 21-acetate Request for quotation
CAS: 356-12-7
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 356-12-7
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Multiple SpecificationsSpot supply
Product Name: Fluocinolone acetonide Visit Supplier Webpage Request for quotationCAS: 356-12-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History